| Name | Tannic acid | ||
| PubChem CID | 16129778 | ||
| Molecular Weight | 1701.2g/mol | ||
| Formula | C₇₆H₅₂O₄₆ | ||
| SMILES | C1=C(C=C(C(=C1O)O)O)C(=O)OC2=CC(=CC(=C2O)O)C(=O)OCC3C(C(C(C(O3)OC(=O)C4=CC(=C(C(=C4)OC(=O)C5=CC(=C(C(=C5)O)O)O)O)O)OC(=O)C6=CC(=C(C(=C6)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)O)OC(=O)C8=CC(=C(C(=C8)OC(=O)C9=CC(=C(C(=C9)O)O)O)O)O)OC(=O)C1=CC(=C(C(=C1)OC(=O)C1=CC(=C(C(=C1)O)O)O)O)O | ||
| InChI | 1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2/t52-,63-,64+,65-,76+/m1/s1 | ||
| InChIKey | LRBQNJMCXXYXIU-PPKXGCFTSA-N | ||
| CAS Number | 1401-55-4 | ||
| ChEMBL ID | CHEMBL506247 | ||
| ChEBI ID | CHEBI:81066 | ||
| Drug Bank ID | DB09372 | ||
| KEGG ID | C17409 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | BaiShao | ||
| Use Part | Root | ||
| Habitat | ZheJiang, AnHui, SiChuan | ||
| Flavor | Bitter, Sour | ||
| Meridian Tropism | Liver, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Saxifragales
-->Family: Paeoniaceae
-->Genus: Paeonia
-->Species: Paeonia lactiflora
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| Chineses Pinyin | YuZhua | ||
| Use Part | Rhizome | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung; Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Asparagaceae
-->Genus: Polygonatum
-->Species: Polygonatum odoratum
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| Pair Name | Tannic acid, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Mitochondria-mediated apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| Result | The results obtained from the present study suggest that the combination of TA and CDDP may exert synergistic anticancer effects and may be a novel adjuvant treatment for liver cancer. | |||
| Pair Name | Tannic acid, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Up-regulation | Expression | ATF6 | hsa22926 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Expression | EIF2AK3 | hsa9451 | |
| Up-regulation | Expression | EIF2S1 | hsa1965 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| GLC-82 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_3371 | |
| In Vivo Model | Cells (1×10⁷) were suspended in 200 µL 0.9% saline and injected subcutaneously into the axilla of 6-week-old mice for 7 d. | |||
| Result | The combination of TA and CDDP may produce synergistic antitumoral effects mediated by the PERK-ATF4-CHOP apoptotic axis, suggesting a novel adjuvant treatment for lung cancer. | |||
| Pair Name | Tannic acid, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| RAW 264.7 | Leukemia | Mus musculus (Mouse) | CVCL_0493 | |
| In Vivo Model | Mice were subcutaneously inoculated with LLC cells (1×10⁶/mouse) in 0.1 ml of PBS at the armpit of the foreleg. | |||
| Result | Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis. Oncol Rep. 2019 Nov;42(5):2108-2116. doi: 10.3892/or.2019.7281. | Click |
| 2 | Synergistic anticancer activity of cisplatin combined with tannic acid enhances apoptosis in lung cancer through the PERK-ATF4 pathway. Eur J Med Res. 2023 Oct 27;28(1):462. doi: 10.1186/s40001-023-01420-z. | Click |
| 3 | Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death. Phytomedicine. 2024 Jan;123:155219. doi: 10.1016/j.phymed.2023.155219. | Click |
